Overview

  • Product name
  • Description
    Rabbit polyclonal to OASL
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (AVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKVGSFGNGTVLRSTREVEL V) of Human OASL, NP_937856

  • Positive control
    • Fetal brain lysate (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab86124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 59 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
  • Tissue specificity
    Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
  • Sequence similarities
    Belongs to the 2-5A synthase family.
    Contains 2 ubiquitin-like domains.
  • Domain
    The ubiquitin-like domains are essential for its antiviral activity.
  • Cellular localization
    Cytoplasm and Nucleus > nucleolus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2' 5' oligoadenylate synthetase like antibody
    • 2''-5''-OAS-related protein antibody
    • 2''-5''-OAS-RP antibody
    • 2''-5''-oligoadenylate synthase-like protein antibody
    • 2'-5' oligoadenylate synthetase-like 2 antibody
    • 2'-5'-oligoadenylate synthetase-like antibody
    • 59 kDa 2' 5' oligoadenylate synthetase like protein antibody
    • 59 kDa 2''-5''-oligoadenylate synthase-like protein antibody
    • 59 kDa 2'-5'-oligoadenylate synthetase-like protein antibody
    • M1204 antibody
    • Mmu-OASL antibody
    • OASL antibody
    • OASL_HUMAN antibody
    • Oasl2 antibody
    • p59 OASL antibody
    • p59OASL antibody
    • THYROID HORMONE RECEPTOR INTERACTOR 14 antibody
    • Thyroid receptor interacting protein 14 antibody
    • Thyroid receptor-interacting protein 14 antibody
    • TR-interacting protein 14 antibody
    • TRIP-14 antibody
    • TRIP14 antibody
    see all

Images

  • Anti-OASL antibody (ab86124) at 1 µg/ml + Fetal brain lysate (Human) at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 59 kDa
    Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.

References

ab86124 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab86124.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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