Overview

  • Product nameAnti-OATP2 antibody [ESL]
    See all OATP2 primary antibodies
  • Description
    Mouse monoclonal [ESL] to OATP2
  • SpecificityThis antibody shows no cross-reactivity to other OATP isoforms.
  • Tested applicationsSuitable for: IHC-P, ICC/IF, WB, IPmore details
  • Species reactivity
    Reacts with: Human, Xenopus laevis
    Does not react with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide corresponding to Human OATP2 aa 671-691.
    Sequence:

    ESLNKNKHFVPSAGADSETHC

  • Positive control
    • Human liver tissue slides.

Properties

Applications

Our Abpromise guarantee covers the use of ab15441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ICC/IF 1/100. PubMed: 21173039
WB 1/1000.
IP Use at an assay dependent concentration.

Target

  • FunctionMediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
  • Tissue specificityHighly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
  • Sequence similaritiesBelongs to the organo anion transporter (TC 2.A.60) family.
    Contains 1 Kazal-like domain.
  • Cellular localizationBasolateral cell membrane. Detected in basolateral membranes of hepatocytes.
  • Information by UniProt
  • Database links
  • Alternative names
    • Liver-specific organic anion transporter 1 antibody
    • LST-1 antibody
    • LST1 antibody
    • OATP-2 antibody
    • OATP-C antibody
    • OATP1B1 antibody
    • OATPC antibody
    • SLC21A6 antibody
    • SLCO1B1 antibody
    • SO1B1_HUMAN antibody
    • Sodium-independent organic anion-transporting polypeptide 2 antibody
    • Solute carrier family 21 member 6 antibody
    • Solute carrier organic anion transporter family member 1B1 antibody
    see all

References for Anti-OATP2 antibody [ESL] (ab15441)

This product has been referenced in:
  • van de Steeg E  et al. Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1. Drug Metab Dispos 41:592-601 (2013). ICC/IF ; Human . Read more (PubMed: 23248200) »
  • Martinez-Becerra P  et al. Further Characterization of the Electrogenicity and pH Sensitivity of the Human Organic Anion-Transporting Polypeptides OATP1B1 and OATP1B3. Mol Pharmacol 79:596-607 (2011). ICC/IF ; Xenopus laevis . Read more (PubMed: 21173039) »

See all 2 Publications for this product

Product Wall



Any products that require an MSDS form will have a link on the product's online datasheet to the data. It will be a PDF document link labeled 'SDS'. Please see attached image for example of what to look for on the datasheet. If no 'SDS' link ...

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Thank you for getting back to me with this case.

I am glad that the customer has received the replacement product. I can confirm that this antibody has detected a band of ˜85 kDa in liver basolateral membrane as well as a band of ˜90 kDa in t...

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Thank you for your enquiry. Both antibodies were tested in IP using human liver samples (~20-50 ug) and about 1 ug/ml of antibody used. For IF, human liver and transfected HEK293 whole cell lysates were used. Ab15442 was used at a dilution of 1:20. The...

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