Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Belongs to the ODC antizyme family.
Expression starts early in spermiogenesis and finishes in the late spermatid phase.