Overview

  • Product nameAnti-OBSCN antibody
    See all OBSCN primary antibodies
  • Description
    Rabbit polyclonal to OBSCN
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen, corresponding to amino acids 5215-5318 of Human OBSCN.

  • Positive control
    • Human urinary bladder tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionInvolved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 DH (DBL-homology) domain.
    Contains 3 fibronectin type-III domains.
    Contains 55 Ig-like (immunoglobulin-like) domains.
    Contains 1 IQ domain.
    Contains 2 PH domains.
    Contains 2 protein kinase domains.
    Contains 1 SH3 domain.
  • Cellular localizationCytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • BC046431 antibody
    • Gm878 antibody
    • KIAA1556 antibody
    • KIAA1639 antibody
    • OBSCN antibody
    • OBSCN_HUMAN antibody
    • Obscurin antibody
    • Obscurin-MLCK antibody
    • Obscurin-myosin light chain kinase antibody
    • Obscurin-RhoGEF antibody
    • OTTMUSG00000005786 antibody
    • UNC89 antibody
    see all

Anti-OBSCN antibody images

  • ab121605 at 1/250 dilution staining OBSCN in Paraffin-embedded Human urinary bladder tissue by Immunohistochemistry.
    Note:strong cytoplasmic positivity in urothelial cells.

References for Anti-OBSCN antibody (ab121605)

ab121605 has not yet been referenced specifically in any publications.

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