Overview

  • Product nameODQ
  • Description
    Selective, potent inhibitor of NO-sensitive guanylyl cyclase
  • Biological descriptionSelective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.
  • Purity> 99%

Properties

  • Chemical name1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
  • Molecular weight187.16
  • Chemical structureChemical Structure
  • Molecular formulaC9H5N3O2
  • CAS Number41443-28-1
  • PubChem identifier1456
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C2ON=C3C=Nc1ccccc1N23
  • Source

    Synthetic

  • Research areas

    References for ODQ (ab120022)

    This product has been referenced in:
    • Homer KL  et al. Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation. J Pharm Pharmacol 51:135-9 (1999). Read more (PubMed: 10217311) »
    • Schrammel A  et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50:1-5 (1996). Read more (PubMed: 8700100) »
    • Garthwaite J  et al. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48:184-8 (1995). Read more (PubMed: 7544433) »

    See all 3 Publications for this product

    Product Wall

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