WB: Preliminary experiments in Human brain lysates and in lysates of cell line NIH 3T3 gave no specific signal but low background (at antibody concentration up to 1µg/ml).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionInvolved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer.
Tissue specificityExpressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.
Involvement in diseaseMicrophthalmia, isolated, with coloboma, 9
Sequence similaritiesBelongs to the tenascin family. Teneurin subfamily. Contains 8 EGF-like domains. Contains 5 NHL repeats. Contains 1 teneurin N-terminal domain. Contains 23 YD repeats.
DomainEGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
ab82575 staining ODZ in human cerebellum tissue by Immunohistochemistry (Formalin/PFA fixed paraffin embedded sections). Primary antibody used at 1.5µg/ml. Note the nuclear staining of the granular cell layer.