Overview

  • Product nameAnti-OFD1 antibody
  • Description
    Rabbit polyclonal to OFD1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to a region within N-terminal amino acids 2-51 (AQSTMPHKCD DVLSQDELRK KLYQTFKDRG ILDTLKTQLR NQLVHELMHP) of Rat OFD1 (NP_001100431).

  • Positive control
    • Rat liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab122960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 118 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionComponent of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation.
  • Tissue specificityWidely expressed. Expressed in 9 and 14 weeks old embryos in metanephric mesenchyme, oral mucosa, lung, heart, nasal and cranial cartilage, and brain. Expressed in metanephros, brain, tongue, and limb.
  • Involvement in diseaseOrofaciodigital syndrome 1
    Simpson-Golabi-Behmel syndrome 2
    Joubert syndrome 10
    Retinitis pigmentosa 23
  • Sequence similaritiesBelongs to the OFD1 family.
    Contains 1 LisH domain.
  • Cellular localizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310).
  • Information by UniProt
  • Database links
  • Alternative names
    • 71 7A antibody
    • 717A antibody
    • CXorf5 antibody
    • JBTS10 antibody
    • Ofd1 antibody
    • OFD1_HUMAN antibody
    • oral facial digital syndrome 1 antibody
    • Oral-facial-digital syndrome 1 protein antibody
    • OTTHUMP00000022941 antibody
    • Protein 71-7A antibody
    • RGD1562231 antibody
    • SGBS2 antibody
    see all

Anti-OFD1 antibody images

  • Anti-OFD1 antibody (ab122960) at 1 µg/ml + Rat liver lysate at 10 µg

    Predicted band size : 118 kDa

References for Anti-OFD1 antibody (ab122960)

ab122960 has not yet been referenced specifically in any publications.

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