Anti-OGR1 antibody (ab61420)
Key features and details
- Rabbit polyclonal to OGR1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-OGR1 antibody
See all OGR1 primary antibodies -
Description
Rabbit polyclonal to OGR1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human OGR1 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
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Positive control
- Human Testis.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.70
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab61420 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
Use a concentration of 20 µg/ml.
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Notes |
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IHC-P
Use a concentration of 20 µg/ml. |
Target
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Function
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. -
Tissue specificity
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 8111 Human
- Entrez Gene: 238377 Mouse
- Omim: 601404 Human
- SwissProt: Q15743 Human
- SwissProt: Q8BFQ3 Mouse
- Unigene: 8882 Human
- Unigene: 32160 Mouse
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Alternative names
- G protein coupled receptor 68 antibody
- G-protein coupled receptor 68 antibody
- GPR 12A antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab61420 has been referenced in 2 publications.
- Herzig M et al. Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody. Int J Mol Sci 20:N/A (2019). PubMed: 31652823
- Wiley SZ et al. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J 32:1170-1183 (2018). PubMed: 29092903