Overview

  • Product nameOlanzapine
  • Description
    Non-selective 5-HT, dopamine, histamine and muscarinic antagonist
  • Biological description5-HT and D2 antagonist (Ki values are 4 (5-HT2A), 11 (5-HT2C) and 57 (5-HT3), 31 (D1), 11 (D2) and 27 nM (D4)). Additionally, displays activity at: M1, M2, M3, M4, H1, α1 and α2 receptors (Ki are 1.9 at (M1), 18 (M2), 25 (M3), 13 (M4), 19 (α1) and 7 nM (α2)). Atypical antipsychotic. Displays anxiolytic activity.
  • Purity> 99%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120736 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Olanzapine images

    • ab32572 staining β catenin in SKNSH cells treated with olanzapine (ab120736), by ICC/IF. Increase in expression of β catenin correlates with increased concentration of olanzapine, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120736 (olanzapine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32572 (1/200 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for Olanzapine (ab120736)

    This product has been referenced in:
    • Sun T  et al. Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats. Pharmacol Biochem Behav 95:298-307 (2010). Read more (PubMed: 20167232) »
    • Raedler TJ  et al. In vivo olanzapine occupancy of muscarinic acetylcholine receptors in patients with schizophrenia. Neuropsychopharmacology 23:56-68 (2000). Read more (PubMed: 10869886) »
    • Bymaster FP  et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14:87-96 (1996). Read more (PubMed: 8822531) »

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