Overview

  • Product name
  • Description
    Rabbit polyclonal to Olig1
  • Tested applications
    Suitable for: IHC-FoFr, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Human, Pig, Chimpanzee, Monkey, Baboon, Common marmoset
  • Immunogen

    Synthetic peptide:

    SARPDAKEEQQQQLR-C

    , corresponding to amino acids 93-107 of Human Olig1

  • Positive control
    • White matter of adult rat spinal cord.

Properties

Applications

Our Abpromise guarantee covers the use of ab68105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration. PubMed: 23840470
IHC-Fr 1/100 - 1/600.

Target

  • Function
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • Tissue specificity
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
  • Sequence similarities
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Basic domain helix loop helix protein class B 6 antibody
    • Basic domain helix loop helix protein class B6 antibody
    • BHLH B6 antibody
    • BHLHB 6 antibody
    • bHLHb6 antibody
    • bHLHe21 antibody
    • Class B basic helix-loop-helix protein 6 antibody
    • Class E basic helix-loop-helix protein 21 antibody
    • Olig 1 antibody
    • Olig1 antibody
    • OLIG1_HUMAN antibody
    • Oligo 1 antibody
    • Oligo1 antibody
    • Oligodendrocyte lineage transcription factor 1 antibody
    • Oligodendrocyte specific bHLH transcription factor 1 antibody
    • Oligodendrocyte transcription factor 1 antibody
    see all

Images

  • ab68105, at 1/100 dilution, staining Olig1 in the white matter of adult rat spinal cord by Immunohistochemistry on cryo-preserved sections, using anti-rabbit Cy3-conjugated secondary antibodies (red) and DAPI (blue) as a nuclear counterstain.

References

This product has been referenced in:
  • Szymanski CR  et al. Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment. PLoS One 8:e66448 (2013). IHC-FoFr ; Rat . Read more (PubMed: 23840470) »
  • Jakovcevski I & Zecevic N Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. J Neurosci 25:10064-73 (2005). Read more (PubMed: 16267213) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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