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2+ channel blocker (N type)
Synthetic toxin originally isolated from
Conus geographus. Specific blocker of Cav2.2 (N-type) Ca 2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.
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120H 182N 38O 43S 6
CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: C-terminal amide; X-4 = Hyp; X-10 = Hyp; X-21 = Hyp; Disulfide bonds: 1-16, 8-19, 15-26)
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our
frequently asked questions (FAQ) page for more details.
References for ω-Conotoxin GVIA (ab120215)
This product has been referenced in:
Terlau H & Olivera BM
Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84:41-68 (2004).
Read more (PubMed: 14715910) »
et al. Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J Biol Chem 276:15728-35 (2001).
Read more (PubMed: 11279062) »
et al. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem 63:823-67 (1994).
Read more (PubMed: 7979255) »
See all 8 Publications
for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"