Overview

  • Product name
    ω-Conotoxin GVIA
  • Description
    Ca2+ channel blocker (N type)
  • Biological description
    Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.
  • Purity
    > 96%
  • General notes
    To purchase this product, additional information may be required for security reasons. Please contact customer services for further details.

Properties

References

This product has been referenced in:
  • Terlau H & Olivera BM Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84:41-68 (2004). Read more (PubMed: 14715910) »
  • Feng ZP  et al. Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J Biol Chem 276:15728-35 (2001). Read more (PubMed: 11279062) »
  • Olivera BM  et al. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem 63:823-67 (1994). Read more (PubMed: 7979255) »

See all 8 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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