Anti-ORC6L antibody [3A4] - ChIP Grade (ab22536)

Overview

  • Product nameAnti-ORC6L antibody [3A4] - ChIP Grade
    See all ORC6L primary antibodies
  • Description
    Rat monoclonal [3A4] to ORC6L - ChIP Grade
  • Specificityab22536 recognises ORC6L.
  • Tested applicationsSuitable for: IP, WB, ChIPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human): ORC6L

Properties

Applications

Our Abpromise guarantee covers the use of ab22536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 28 kDa.
ChIP Use at an assay dependent dilution.

Target

  • FunctionComponent of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • Involvement in diseaseDefects in ORC6 are the cause of Meier-Gorlin syndrome type 3 (MGORS3) [MIM:613803]. MGORS3 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • Sequence similaritiesBelongs to the ORC6 family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ORC 6 antibody
    • Orc6 antibody
    • ORC6_HUMAN antibody
    • ORC6L antibody
    • Origin recognition complex subunit 6 antibody
    • origin recognition complex subunit 6 homolog like antibody
    • origin recognition complex subunit 6 homolog like (yeast) antibody
    • origin recognition complex subunit 6 like (yeast) antibody
    see all

References for Anti-ORC6L antibody [3A4] - ChIP Grade (ab22536)

ab22536 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. At Abcam we qualify all of our "ChIP grade" antisera in two ways. Firstly we operate an in house ChIP testing programme with an in house development scientist. Secondly we collaborate with groups that have extensive experien...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"