Overview

  • Product name
    Anti-Orexin Receptor 2 antibody
    See all Orexin Receptor 2 primary antibodies
  • Description
    Goat polyclonal to Orexin Receptor 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to Human Orexin Receptor 2 aa 2-14 (N terminal).
    Sequence:

    SGTKLEDSPPCRN

  • Positive control
    • WB: Human brain (Hippocampus) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab65093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).

Target

  • Function
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Domain
    The N-terminal region is required for orexin signaling.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hcr tr2 antibody
    • Hcrt receptor 2 antibody
    • Hcrtr2 antibody
    • Hypocretin (orexin) receptor 2 antibody
    • Hypocretin receptor 2 antibody
    • Hypocretin receptor type 2 antibody
    • Orexin 2 receptor antibody
    • Orexin A/Orexin B receptor antibody
    • Orexin receptor 2 antibody
    • Orexin receptor type 2 antibody
    • Orexin type 2 receptor antibody
    • Ox-2-R antibody
    • Ox2-R antibody
    • Ox2r antibody
    • OX2R_HUMAN antibody
    • Type 2 hypocretin receptor antibody
    • Type 2 orexin receptor antibody
    see all

Images

  • Anti-Orexin Receptor 2 antibody (ab65093) at 1 µg/ml + Human brain (Hippocampus) lysate (in RIPA buffer). at 35 µg
    Developed using the ECL technique

    Predicted band size : 51 kDa
    Observed band size : 51 kDa

    Primary incubation was 1 hour.

References

This product has been referenced in:
  • Ahmed SS  et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Sci Transl Med 7:294ra105 (2015). Read more (PubMed: 26136476) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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