Overview

  • Product name
  • Description
    Rabbit polyclonal to ORMDL3
  • Specificity
    ab107639 may cross-react with ORMDL1 and ORMDL2.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human ORMDL3 aa 53-81 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: Q8N138

  • Positive control
    • WB: Mouse testis tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab107639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 17 kDa.

Target

  • Function
    Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
  • Tissue specificity
    Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
  • Involvement in disease
    Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
  • Sequence similarities
    Belongs to the ORM family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ORM1 (S. cerevisiae)-like 3 antibody
    • ORM1-like 3 (S. cerevisiae) antibody
    • ORM1-like 3 antibody
    • ORM1-like protein 3 antibody
    • ORMDL sphingolipid biosynthesis regulator 3 antibody
    • Ormdl3 antibody
    • ORML3_HUMAN antibody
    • OTTHUMP00000164334 antibody
    see all

Anti-ORMDL3 antibody images

  • All lanes : Anti-ORMDL3 antibody (ab107639) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Mouse testis lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

    Predicted band size : 17 kDa

    Blocking buffer 5% NFDM/TBST
    Diluting buffer  5% NFDM/TBST

References for Anti-ORMDL3 antibody (ab107639)

This product has been referenced in:
  • Yu F  et al. ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway. Mol Med Rep 15:2969-2976 (2017). WB, IHC-P ; Mouse . Read more (PubMed: 28358425) »
  • Zhuang LL  et al. Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene. PLoS One 8:e60630 (2013). WB ; Mouse . Read more (PubMed: 23577138) »

See all 2 Publications for this product

Product Wall

Yes, product Anti-ORMDL3 antibody (ab107639) is able to detect endogenous ORMDL3 protein in lysate samples, without overexpression.

Western Blot data showing use of ab107639 for the detection of endogenous ORMDL3 in Jurkat whole cell lysates a...

Read More

Yes - product Anti-ORMDL1 + ORMDL2 + ORMDL3 antibody (ab128660) is a pan-specific ORMDL family antibody. It will detect ORMDL1, ORMDL2 and ORMDL3.

Ab128660 is able to detect endogenous ORMDL1-3 in human cell lysates by WB; reactivity against ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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