Anti-Orthoreovirus fusion protein p10 antibody (ab26816)

Overview

  • Product nameAnti-Orthoreovirus fusion protein p10 antibody
  • Description
    Rabbit polyclonal to Orthoreovirus fusion protein p10
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with Avain orthoreovirus Not yet tested in other species.
  • Immunogen

    Synthetic peptide

Properties

Applications

Our Abpromise guarantee covers the use of ab26816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/40000.

Target

  • RelevanceThe p10 fusion-associated small transmembrane protein of avian reovirus induces extensive syncytium formation in transfected cells. The p10-induced cell-cell fusion is restricted by rapid degradation of the majority of newly synthesized p10. The small ectodomain of p10 targets the protein for degradation following p10 insertion into an early membrane compartment. Paradoxically, conservative amino acid substitutions in the p10 ectodomain hydrophobic patch that eliminate fusion activity also increase p10 stability. The small amount of p10 that escapes intracellular degradation accumulates at the cell surface in a relatively stable form, where it mediates cell-cell fusion as a late-stage event in the virus replication cycle. The unusual relationship between a nonstructural viral membrane fusion protein and the replication cycle of a nonenveloped virus has apparently contributed to the evolution of a novel mechanism for restricting the extent of virus-induced cell-cell fusion.
  • Alternative names
    • 10 kDa protein antibody
    • Fusion protein p10 antibody

References for Anti-Orthoreovirus fusion protein p10 antibody (ab26816)

ab26816 has not yet been referenced specifically in any publications.

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