Overview

  • Product nameAnti-OSBP1 antibody
    See all OSBP1 primary antibodies
  • Description
    Goat polyclonal to OSBP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit
  • Immunogen

    Synthetic peptide: CKEKQDWSSCPDIF, corresponding to C terminal amino acids 407-420 of Human OSBP1.

  • General notesGenBank Accession Number – NP_002547

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab5915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesPeptide ELISA: antibody detection limit dilution >1/16000
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 89.4 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionBinds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesBelongs to the OSBP family.
      Contains 1 PH domain.
    • DomainThe PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
      The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
    • Cellular localizationCytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
    • Information by UniProt
    • Database links
    • Alternative names
      • OSBP 1 antibody
      • OSBP antibody
      • OSBP1_HUMAN antibody
      • Oxysterol binding protein 1 antibody
      • Oxysterol-binding protein 1 antibody
      see all

    Anti-OSBP1 antibody images

    References for Anti-OSBP1 antibody (ab5915)

    ab5915 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"