Overview

  • Product name
  • Description
    Goat polyclonal to OSBP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit
  • Immunogen

    Synthetic peptide: CKEKQDWSSCPDIF, corresponding to C terminal amino acids 407-420 of Human OSBP1.

  • General notes
    GenBank Accession Number – NP_002547

Properties

Applications

Our Abpromise guarantee covers the use of ab5915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution >1/16000
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 89.4 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
    • Tissue specificity
      Widely expressed.
    • Sequence similarities
      Belongs to the OSBP family.
      Contains 1 PH domain.
    • Domain
      The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
      The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
    • Cellular localization
      Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
    • Information by UniProt
    • Database links
    • Alternative names
      • OSBP 1 antibody
      • OSBP antibody
      • OSBP1_HUMAN antibody
      • Oxysterol binding protein 1 antibody
      • Oxysterol-binding protein 1 antibody
      see all

    Images

    References

    This product has been referenced in:
    • Wang PX  et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun 7:10592 (2016). Read more (PubMed: 26882989) »
    • Luo P  et al. Hepatic Oncostatin M Receptor ß Regulates Obesity-Induced Steatosis and Insulin Resistance. Am J Pathol 186:1278-92 (2016). Read more (PubMed: 26976243) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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