Overview

  • Product name
  • Description
    Rabbit polyclonal to Osteocalcin
  • Specificity
    There were no cross reactivities obtained with human Osteopontin, human Osteonectin, and human Bone Sialoprotein.
  • Tested applications
    Suitable for: WB, RIA, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Osteocalcin aa 1-22.
    Sequence:

    MRALTLLALLALAALCIAGQAG


    Database link: P02818

Properties

Applications

Our Abpromise guarantee covers the use of ab14173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. PubMed: 18760468
RIA 1/2000.
ELISA 1/5000.

Target

  • Function
    Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
  • Sequence similarities
    Belongs to the osteocalcin/matrix Gla protein family.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Post-translational
    modifications
    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BGLAP antibody
    • BGP antibody
    • Bone gamma carboxyglutamate (gla) protein antibody
    • Bone gamma carboxyglutamate gla protein osteocalcin antibody
    • Bone gamma carboxyglutamate protein antibody
    • Bone Gla protein antibody
    • Gamma carboxyglutamic acid containing protein antibody
    • Gamma-carboxyglutamic acid-containing protein antibody
    • OC antibody
    • OCN antibody
    • OSTCN_HUMAN antibody
    • Osteocalcin antibody
    • OTTHUMP00000016586 antibody
    • PMF1 antibody
    see all

References

This product has been referenced in:
  • Weng L  et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep 6:38632 (2016). IF ; Mouse . Read more (PubMed: 27929130) »
  • Li C  et al. Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res 28:2094-108 (2013). Read more (PubMed: 23609180) »

See all 6 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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