Anti-OXCT1/SCOT antibody (ab105320)
Key features and details
- Rabbit polyclonal to OXCT1/SCOT
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-OXCT1/SCOT antibody
See all OXCT1/SCOT primary antibodies -
Description
Rabbit polyclonal to OXCT1/SCOT -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human OXCT1/SCOT aa 171-434. (BC009001)
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Positive control
- Human fetal heart and brain lysates; Human fetal kidney tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in 200ul sterile water -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab105320 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 56 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 56 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. -
Tissue specificity
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts. -
Pathway
Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. -
Involvement in disease
Succinyl-CoA:3-oxoacid CoA transferase deficiency -
Sequence similarities
Belongs to the 3-oxoacid CoA-transferase family. -
Cellular localization
Mitochondrion matrix. - Information by UniProt
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Database links
- Entrez Gene: 5019 Human
- Entrez Gene: 67041 Mouse
- Entrez Gene: 690163 Rat
- Omim: 601424 Human
- SwissProt: P55809 Human
- SwissProt: Q9D0K2 Mouse
- SwissProt: B2GV06 Rat
- Unigene: 278277 Human
see all -
Alternative names
- 3 oxoacid CoA transferase 1 antibody
- 3-oxoacid CoA-transferase 1 antibody
- EC 2.8.3.5 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab105320 has been referenced in 7 publications.
- Jiang L et al. Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. Bioengineered 12:6559-6571 (2021). PubMed: 34559577
- Thai PN et al. Ketone Ester D-β-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice. J Am Heart Assoc 10:e020729 (2021). PubMed: 34583524
- Assalin HB et al. miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring. PLoS One 14:e0210454 (2019). PubMed: 31034522
- Aghajani Nargesi A et al. Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells. Stem Cell Rev Rep 15:427-438 (2019). PubMed: 30338499
- Schnyder S et al. Muscle PGC-1a is required for long-term systemic and local adaptations to a ketogenic diet in mice. Am J Physiol Endocrinol Metab 312:E437-E446 (2017). PubMed: 28223292
- Svensson K et al. Skeletal muscle PGC-1a modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB J 30:1976-86 (2016). PubMed: 26849960
- Cong W et al. Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374). Am J Physiol Endocrinol Metab 304:E826-35 (2013). PubMed: 23423173