The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10 - 1/50.
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Expressed in some normal epithelial tissues and in some carcinoma cell lines.
Involvement in disease
Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life. Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
Calcium dependent adhesion protein placental antibody
CDH 3 antibody
CDH3 protein antibody
P cadherin (placental) antibody
Placental cadherin antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - P cadherin antibody (ab75718)
ab75718, at a dilution of 1/10, staining P cadherin in formalin fixed, paraffin embedded human prostate carcinoma tissue by Immunohistochemistry. ab75718 was peroxidase conjugated to the secondary antibody, followed by DAB staining.