Anti-P cadherin antibody - N-terminal (ab190076)

Overview

  • Product name
    Anti-P cadherin antibody - N-terminal
    See all P cadherin primary antibodies
  • Description
    Rabbit polyclonal to P cadherin - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human P cadherin (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). NP_001784.2.
    Database link: P22223

  • Positive control
    • Human pancreatic duct and prostate carcinoma tissues; NCI-H292 cells; NIH 3T3 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab190076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

WB 1/1000. Predicted molecular weight: 91 kDa.
IHC-P Use a concentration of 10 µg/ml.

Target

  • Function
    Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • Tissue specificity
    Expressed in some normal epithelial tissues and in some carcinoma cell lines.
  • Involvement in disease
    Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life.
    Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
  • Sequence similarities
    Contains 5 cadherin domains.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CADH3_HUMAN antibody
    • Cadherin 3 antibody
    • Cadherin 3 precursor antibody
    • Cadherin 3 type 1 antibody
    • Cadherin-3 antibody
    • Cadp antibody
    • Calcium dependent adhesion protein placental antibody
    • CDH 3 antibody
    • CDH3 antibody
    • CDH3 protein antibody
    • CDHP antibody
    • HJMD antibody
    • P cadherin (placental) antibody
    • P-cadherin antibody
    • PCAD antibody
    • Placental cadherin antibody
    see all

Images

  • Anti-P cadherin antibody - N-terminal (ab190076) at 1/1000 dilution + NIH 3T3 cell lysate at 35 µg

    Predicted band size: 91 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreatic duct tissue labeling P cadherin with ab190076 at 10 µg/ml.

  • Flow cytometric analysis of NCI-H292 cells labeling P Cadherin with ab190076 at 1/10 dilution (bottom histogram) compared to negative control cells (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue labeling P cadherin with ab190076 at 10 µg/ml, followed by peroxidase-conjugated secondary antibody and DAB staining.

References

ab190076 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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