Overview

  • Product name
    p-Nitropifithrin-α
  • Description
    Cell-permeable p53 inhibitor
  • Biological description
    Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo.
  • Purity
    > 98%
  • General notes

    It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 6 hours a DMSO solution had been found to be completely converted into the tricyclic material. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately.

Properties

  • Chemical name
    1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
  • Molecular weight
    398.27
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H15N3O3S.HBr
  • CAS Number
    389850-21-9
  • PubChem identifier
    11553038
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Unstable; make up solutions fresh and use immediately.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1CCC2=C(C1)N(C(=N)S2)CC(=O)C3=CC=C(C=C3)[N+](=O)[O-].Br
  • Source

    Synthetic

References

This product has been referenced in:
  • Shimizu H  et al. Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-?B and p53 in proximal tubular cells. Life Sci 92:143-8 (2013). Read more (PubMed: 23201429) »
  • Derdak Z  et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol 58:785-91 (2013). Read more (PubMed: 23211317) »
  • Pietrancosta N  et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem 49:3645-52 (2006). Read more (PubMed: 16759106) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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