Anti-P protein antibody (ab83975)


  • Product nameAnti-P protein antibody
    See all P protein primary antibodies
  • Description
    Rabbit polyclonal to P protein
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 468 - 517 (LIAEVIFTNI GGAATAIGDP PNVIIVSNQE LRKMGLDFAG FTAHMFIGIC) of Human P protein (NP_000266)

  • Positive control
    • Placenta lysate.



Our Abpromise guarantee covers the use of ab83975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 93 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionCould be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
  • Involvement in diseaseDefects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides.
  • Sequence similaritiesBelongs to the CitM (TC 2.A.11) transporter family.
  • Cellular localizationMelanosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BEY antibody
    • BEY1 antibody
    • BEY2 antibody
    • BOCA antibody
    • D15S12 antibody
    • EYCL antibody
    • EYCL2 antibody
    • EYCL3 antibody
    • eye color 2 (central brown) antibody
    • eye color 3 (brown) antibody
    • hair color 3 (brown) antibody
    • HCL3 antibody
    • Melanocyte-specific transporter protein antibody
    • OCA2 antibody
    • oculocutaneous albinism II antibody
    • oculocutaneous albinism II (pink-eye dilution homolog, mouse) antibody
    • P antibody
    • P protein antibody
    • P_HUMAN antibody
    • PED antibody
    • Pink eyed dilution protein homolog antibody
    • Pink-eyed dilution protein homolog antibody
    • SHEP1 antibody
    • total brown iris pigmentation antibody
    see all

Anti-P protein antibody images

  • Anti-P protein antibody (ab83975) at 1 µg/ml (in 5% skim milk / PBS buffer) + placenta lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 93 kDa
    Observed band size : >90 kDa (why is the actual band size different from the predicted?)

References for Anti-P protein antibody (ab83975)

ab83975 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (midbrain)
Loading amount 50 µg
Specification midbrain
Gel Running Conditions Reduced Denaturing (10%)
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: RT°C

Dr. Jingqiong Kang

Verified customer

Submitted Nov 14 2012

Expiration date: March 10, 2013
Value: $337

This code will give you $337 off your next order before the expiration date. To redeem this offer, please submit an Abreview for ab83975 and include this code in the &ld...

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