Overview

  • Product name
    Anti-p15 INK4b antibody [DCS-114]
    See all p15 INK4b primary antibodies
  • Description
    Mouse monoclonal [DCS-114] to p15 INK4b
  • Tested applications
    Suitable for: ICC/IF, IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Purified recombinant full length protein (Human)

  • Positive control
    • Ls174T cells

Properties

Applications

Our Abpromise guarantee covers the use of ab44891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
IP
  • Application notes
    ICC/IF: Use at an assay dependent dilution.
    IP (Native verified): 1/400 (Use Protein G. Co-precipitation of cdk4/cdk6)

    Is unsuitable for WB.
    Is unsuitable for Immunohistology.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
    • Sequence similarities
      Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
      Contains 4 ANK repeats.
    • Information by UniProt
    • Database links
    • Alternative names
      • CDK inhibitory protein antibody
      • CDK4B Inhibitor antibody
      • Cdkn2b antibody
      • CDN2B_HUMAN antibody
      • Cyclin dependent kinase 4 inhibitor B antibody
      • Cyclin Dependent Kinase Inhibitor 2B antibody
      • Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4 antibody
      • Cyclin dependent kinases 4 and 6 binding protein antibody
      • Cyclin-dependent kinase 4 inhibitor B antibody
      • INK4B antibody
      • MTS 2 antibody
      • MTS-2 antibody
      • MTS2 antibody
      • Multiple tumor suppressor 2 antibody
      • Multiple Tumor Supressor 2 antibody
      • OTTHUMP00000021154 antibody
      • OTTHUMP00000021155 antibody
      • p14 CDK inhibitor antibody
      • p14 INK4b antibody
      • p14-INK4b antibody
      • P15 antibody
      • p15 CDK inhibitor antibody
      • p15 inhibits CDK4 antibody
      • p15 INK4b antibody
      • p15-INK4b antibody
      • p15INK4B antibody
      • TP 15 antibody
      • TP15 antibody
      see all

    References

    This product has been referenced in:
    • Gray-Bablin J  et al. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. Cancer Res 57:604-9 (1997). Read more (PubMed: 9044834) »
    • Naumann M  et al. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 110:1215-24 (1996). Read more (PubMed: 8613012) »

    See all 4 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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