Overview

  • Product name
    p15 INK4b peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab109892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-p15 INK4b antibody (ab94688)

  • Purity
    70 - 90% by HPLC.

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • CDK inhibitory protein
    • CDK4B Inhibitor
    • Cdkn2b
    • CDN2B_HUMAN
    • Cyclin dependent kinase 4 inhibitor B
    • Cyclin Dependent Kinase Inhibitor 2B
    • Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4
    • Cyclin dependent kinases 4 and 6 binding protein
    • Cyclin-dependent kinase 4 inhibitor B
    • INK4B
    • MTS 2
    • MTS-2
    • MTS2
    • Multiple tumor suppressor 2
    • Multiple Tumor Supressor 2
    • OTTHUMP00000021154
    • OTTHUMP00000021155
    • p14 CDK inhibitor
    • p14 INK4b
    • p14-INK4b
    • P15
    • p15 CDK inhibitor
    • p15 inhibits CDK4
    • p15 INK4b
    • p15-INK4b
    • p15INK4B
    • TP 15
    • TP15
    see all
  • Function
    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
  • Sequence similarities
    Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
    Contains 4 ANK repeats.
  • Information by UniProt

References

ab109892 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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