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Product name
p16 INK4a peptide
See all CDKN2A/p16INK4a products (3) ...
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 100ug BSA 0.1% sodium azide
Concentration
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Sequence notes
Synthetic peptide mapping to the carboxy terminal domain of human p16
Research areas
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> INK4a/Arf
Cancer >> Cell cycle >> Cell cycle inhibitors >> Ink4
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Ink4
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Ink4
Applications
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Our Abpromise guarantee covers the use of ab8017 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
Blocking peptide for Rabbit polyclonal to p16 (ab7962)
Protein info
Relevance
The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.
Cellular localization
Cytoplasmic and Nuclear
References for p16 INK4a peptide (ab8017)
ab8017 has not yet been referenced specifically in any publications.
Publishing research using ab8017? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"