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Product Name
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p19 INK4d antibody [IMD-19]
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See all p19 INK4d antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [IMD-19] to p19 INK4d
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Immunogen
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Recombinant human p19INK4d.
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ICC, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions ICC: Use at an assay dependent dilution. IHC-P: Use at a concentration of 1 - 2 µg/ml. WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 17 kDa.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> INK4a/Arf Chromatin and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Ink4 Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Ink4
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Relevance
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Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclindependent kinases. The activity of the cyclin D dependent kinases is controlled by inhibitors such as the INK4 family, which includes INK4a, INK4b, INK4c, and INK4d. The p19 protein, also known as INK4d was first identified in a yeast two-hybrid system screened for CDK4 binding proteins(Hirai H, et al. Molec. Cell. Biol. 15: 2672-2681, 1995). Human p19 shares 86% identity at the amino acid level with murine p19, and is approximately 44% identical to each of the other human INK4 family members (Okuda, T. et al. Genomics 29: 623-630, 1995). p19 INK4d is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during cell cycle. It is maximally induced as cells enter S phase.
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Database links
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The links below go to external sites and will open in a new browser window
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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IMD-19
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Isotype
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IgG1
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide Constituents: 1.2% Sodium acetate, 2mg BSA Material safety datasheet (MSDS) for this product: Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this p19 INK4d antibody [IMD-19] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to p19 INK4d
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