p19 INK4d antibody [IMD-19] (ab82261)

Product Name 

p19 INK4d antibody [IMD-19]

Product type 

Primary antibodies

Description 

Mouse monoclonal [IMD-19] to p19 INK4d

Immunogen 

Recombinant human p19INK4d.

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ICC, IHC-P, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
ICC: Use at an assay dependent dilution.
IHC-P: Use at a concentration of 1 - 2 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 17 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> INK4a/Arf
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Ink4
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Ink4

Relevance 

Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclindependent kinases. The activity of the cyclin D dependent kinases is controlled by inhibitors such as the INK4 family, which includes INK4a, INK4b, INK4c, and INK4d. The p19 protein, also known as INK4d was first identified in a yeast two-hybrid system screened for CDK4 binding proteins(Hirai H, et al. Molec. Cell. Biol. 15: 2672-2681, 1995). Human p19 shares 86% identity at the amino acid level with murine p19, and is approximately 44% identical to each of the other human INK4 family members (Okuda, T. et al. Genomics 29: 623-630, 1995). p19 INK4d is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during cell cycle. It is maximally induced as cells enter S phase.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

IMD-19

Isotype 

IgG1

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: 1.2% Sodium acetate, 2mg BSA

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.100 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

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