Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence

    Specifications

    Our Abpromise guarantee covers the use of ab191248 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking

    • Form
      Liquid
    • Additional notes

      This is the blocking peptide for ab109246

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

    General Info

    • Alternative names
      • ATP receptor
      • P2rx7
      • P2RX7_HUMAN
      • P2X purinoceptor 7
      • P2X7
      • P2Z receptor
      • Purinergic receptor
      • purinergic receptor P2X, ligand gated ion channel, 7
      see all
    • Function
      Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
    • Tissue specificity
      Widely expressed with highest levels in brain and immune tissues.
    • Sequence similarities
      Belongs to the P2X receptor family.
    • Post-translational
      modifications
      Phosphorylation results in its inactivation.
      ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.
      Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
    • Cellular localization
      Cell membrane.
    • Information by UniProt

    References

    ab191248 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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