Overview

  • Product nameAnti-P2X2 antibody
    See all P2X2 primary antibodies
  • Description
    Rabbit polyclonal to P2X2
  • Tested applicationsSuitable for: WB, IHC-Fr, ICC, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Guinea pig, Non Human Primates
  • Immunogen

    Synthetic peptide:

    DSTSTDPKGLAQL

    , corresponding to amino acids 460-472 of Rat P2X2.

Properties

Applications

Our Abpromise guarantee covers the use of ab10266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 47,8 kDa.
IHC-Fr 1/1000.
ICC 1/1000.
IHC-P Use at an assay dependent concentration. PubMed: 21969132

Target

  • FunctionIon channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
  • Involvement in diseaseDeafness, autosomal dominant, 41
  • Sequence similaritiesBelongs to the P2X receptor family.
  • Cellular localizationCell membrane. Localizes to the apical membranes of hair cells in the organ of Corti.
  • Information by UniProt
  • Database links
  • FormThere are 7 isoforms produced by alternative splicing.
  • Alternative names
    • ATP receptor antibody
    • MGC129601 antibody
    • P2RX 2 antibody
    • P2RX2 antibody
    • P2RX2_HUMAN antibody
    • P2X purinoceptor 2 antibody
    • P2X Receptor subunit 2 antibody
    • P2X2 antibody
    • P2X2a antibody
    • Purinergic receptor antibody
    • Purinergic receptor P2X ligand gated ion channel 2 antibody
    • Purinergic receptor P2X2 isoform A antibody
    • Purinergic receptor P2X2 isoform B antibody
    • Purinergic receptor P2X2 isoform C antibody
    • Purinergic receptor P2X2 isoform D antibody
    • Purinergic receptor P2X2 isoform H antibody
    • Purinergic receptor P2X2 isoform I antibody
    see all

Anti-P2X2 antibody images

  • ab10266, at a dilution of 1/1000, staining P2X2 in rat brain stem by Immunohistochemistry (PFA perfusion fixed frozen sections).

References for Anti-P2X2 antibody (ab10266)

This product has been referenced in:
  • Kútna V  et al. Enigmatic cerebrospinal fluid-contacting neurons arise even after the termination of neurogenesis in the rat spinal cord during embryonic development and retain their immature-like characteristics until adulthood. Acta Histochem N/A:N/A (2013). Read more (PubMed: 24063862) »
  • Wu T  et al. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol 301:H69-78 (2011). Read more (PubMed: 21460192) »

See all 3 Publications for this product

Product Wall

Thank you for your inquiry.

As you correctly suspected, we do not know the concentration of the antibody.

Antibody concentration is usually measured by measuring the protein content. Since there are many different proteins in whole ...

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Thank you for your inquiry. To our knowledge, ab10266 has not yet been tested in flow cytometry. It is possible that this product may be suitable for your experiment since it has been successfully used in ICC, but we don't have any data regarding its ...

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Thank you for your enquiry. Antibodies ab10262 and ab10266 are raised against the same peptide which, according to the map found at the link to the SwissProt entry with accession number P49653, is found on a cytoplasmic domain of the protein. I h...

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Thank you for your enquiry and for your patience. The epitopes are intracellular for both ab10266 and ab10267. So unfortunately, they will not suit your needs. If you have any more questions, please contact us again.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"