Overview

  • Product name
  • Description
    Rabbit polyclonal to P2Y4
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human P2Y4.
    Database link: P51582

  • Positive control
    • K562 cell lysate extracts and Human lung cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab180718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/500 - 1/2000. Predicted molecular weight: 41 kDa.

Target

  • Function
    Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
  • Tissue specificity
    Pancreas.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • NRU antibody
    • Nucleotide receptor uridine antibody
    • P2P antibody
    • P2ry4 antibody
    • P2RY4_HUMAN antibody
    • P2Y purinoceptor 4 antibody
    • P2Y4 antibody
    • P2Y4R antibody
    • Pyrimidinergic receptor P2Y G protein coupled 4 antibody
    • UNR antibody
    • Uridine nucleotide receptor antibody
    see all

Images

  • Anti-P2Y4 antibody (ab180718) at 1/500 dilution + K562 cell extracts

    Predicted band size : 41 kDa
  • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling P2Y4 using ab180718 at a 1/50 dilution.

References

This product has been referenced in:
  • Uda Y  et al. P2Y4 Nucleotide Receptor in Neuronal Precursors Induces Glutamatergic Subtype Markers in Their Descendant Neurons. Stem Cell Reports 6:474-482 (2016). Read more (PubMed: 26972684) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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