Anti-p38 antibody (ab89688)

Overview

• Product nameAnti-p38 antibodySee all p38 primary antibodies ...
• Description
  Mouse polyclonal to p38
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length human p38 protein (NP_620581.1).

• Positive controlHepG2 cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 1 x PBS, pH 7.2
• Concentration information loading...
• PurityProtein A purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Immunology
  • Innate Immunity
  • TLR Signaling

Applications

Target

• FunctionResponds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
• Tissue specificityBrain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
• Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
  Contains 1 protein kinase domain.
• DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
• Post-translational
  modificationsDually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationCytoplasm. Nucleus.

Target information above from: UniProt accession Q16539 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 1432 Human
  • GenBank: NM_001315 Human
  • GenBank: NM_139012 Human
  • Omim: 600289 Human
  • SwissProt: Q16539 Human
  • Unigene: 485233 Human

• Alternative names
  CSAID Binding Protein 1 antibodyCSAID binding protein antibodyCSAID-binding protein antibody

  Csaids binding protein antibodyCSBP 1 antibodyCSBP 2 antibodyCSBP antibodyCSBP1 antibodyCSBP2 antibodyCSPB1 antibodyCytokine suppressive anti inflammatory drug binding protein antibodyCytokine suppressive anti-inflammatory drug-binding protein antibodyEXIP antibodyMAP kinase 14 antibodyMAP kinase MXI2 antibodyMAP kinase p38 alpha antibodyMAPK 14 antibodyMAPK14 antibodyMAX interacting protein 2 antibodyMAX-interacting protein 2 antibodyMitogen Activated Protein Kinase 14 antibodyMitogen activated protein kinase p38 alpha antibodyMitogen-activated protein kinase 14 antibodyMitogen-activated protein kinase p38 alpha antibodyMK14_HUMAN antibodyMxi 2 antibodyMxi2 antibodyp38 ALPHA antibodyp38 antibodyp38 MAP kinase antibodyp38 MAPK antibodyp38 mitogen activated protein kinase antibodyp38ALPHA antibodyp38alpha Exip antibodyPRKM14 antibodyPRKM15 antibodyRK antibodySAPK 2A antibodySAPK2A antibodyStress Activated Protein Kinase 2A antibody

  see all

Anti-p38 antibody images

• 

  Western blot - p38 antibody (ab89688)
  Anti-p38 antibody (ab89688) at 1 µg/ml + HepG2 cell lysate at 50 µg
  developed using the ECL technique
  
  Predicted band size : 41 kDa
  Observed band size : 41 kDa
  
• 

  Western blot - p38 antibody (ab89688)
  All lanes : Anti-p38 antibody (ab89688) at 1 µg/ml
  
  Lane 1 : cell lysate from p38 transfected 293T cells
  Lane 2 : cell lysate from non transfected 293T cells
  
  Lysates/proteins at 25 µg per lane.
  
  developed using the ECL technique
  
  Predicted band size : 41 kDa
  Observed band size : 41 kDa