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Overview

  • Product namep38 peptideSee all p38 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab27986 - p38 antibody.

    • Properties

  • Purity> 90 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab53314 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking
  • Application notesBL: Use at an assay dependent dilution.
    This peptide can be used with studies using ab27986.
    ab53314 usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        CSAID binding proteinCSAID Binding Protein 1CSAID-binding protein
        Csaids binding proteinCSBPCSBP 1CSBP 2CSBP1CSBP2CSPB 1CSPB1Cytokine suppressive anti inflammatory drug binding proteinCytokine suppressive anti-inflammatory drug-binding proteinEXIPMAP kinase 14MAP kinase MXI2MAP kinase p38 alphaMAPK 14MAPK14MAX interacting protein 2MAX-interacting protein 2Mitogen Activated Protein Kinase 14Mitogen activated protein kinase p38 alphaMitogen-activated protein kinase 14Mitogen-activated protein kinase p38 alphaMK14_HUMANMxi 2Mxi2p38p38 ALPHAp38 MAP kinasep38 MAPKp38 mitogen activated protein kinasep38ALPHAp38alpha ExipPRKM14PRKM15RKSAPK 2ASAPK2AStress Activated Protein Kinase 2A
      see all
  • FunctionResponds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
  • Tissue specificityBrain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Post-translational
    modifications    Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Nucleus.

    • Target information above from: UniProt accession Q16539 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for p38 peptide (ab53314)

    ab53314 has not yet been referenced specifically in any publications.

    Publishing research using ab53314 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"