Human Predicted to work with:
Recombinant fragment, corresponding to internal sequence amino acids 130-396 of Human P4HA3 (BC117333).
Human fetal kidney & liver lysates, Human fetal liver tissue.
FormLyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
FunctionCatalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Tissue specificityHighly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions.
Sequence similaritiesBelongs to the P4HA family. Contains 1 Fe2OG dioxygenase domain. Contains 1 TPR repeat.
Post-translational modificationsN-glycosylation plays no role in the catalytic activity.
ab101657 at 1/100 dilution staining P4HA3 in Human fetal liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
References for Anti-P4HA3 antibody (ab101657)
This product has been referenced in:
Akamatsu T et al. Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences. Fibrogenesis Tissue Repair6:15 (2013).
Read more (PubMed: 23927729) »