p51A antibody (ab2506)

Product Name 

p51A antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to p51A

Immunogen 

Synthetic peptide: CEPRRETPKQSDVFFRHSKPPNRS, corresponding to C terminal amino acids 462-484 of Human p51A (splice isoform 5)
BLAST 'CEPRRETPKQSDVFFRHSKPPNRS' with or

Reacts with 
(species key)

Hu, Ms

Specificity 

This antibody is specific for p51A.
It does not cross react with p51B

Tested applications 
(see key)

ICC, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ICC: 1/300.
WB: 1/1000. Predicted molecular weight: 51 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human K562 and Jurkat cell lines.
Mouse lung, thumus and heart lysate.

Cellular localization 

Nuclear

Research areas 

Chromatin and Nuclear Signaling >> Transcription >> Other factors
Cell Biology >> Apoptosis >> Nucleus >> Other

Relevance 

p51 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

2.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

References for p51A antibody (ab2506)

  This product has been used in:

Osada M et al. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4:839-43 (1998). PubMed: 9662378

If you publish research using ab2506 please let us know so that we can cite the reference on this datasheet.

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