Anti-p51B antibody (ab2505)

Overview

• Product name
  Anti-p51B antibody
• Description
  Rabbit polyclonal to p51B
• Specificity
  This antibody is specific for p51B. It does not cross react with p51A
• Tested applications
  Suitable for: ICC, WBmore details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide:

  CNFDMDARRNKQQRIKEEGE

  , corresponding to C terminal amino acids 662-680 of Human p51B.

  Run BLAST with Run BLAST with
• Positive control
  • Human Cell Line K562.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Cell Biology
  • Apoptosis
  • Nucleus
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Cancer
  • Cell Death
  • Apoptosis
  • Nucleus
  • Other

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • K562 whole cell lysate (ab7911)

Applications

Target

• Relevance
  p51 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
• Cellular localization
  Nuclear
• Database links
  • Entrez Gene: 8626 Human
  • SwissProt: Q9H3D4 Human
• Alternative names
  • AIS antibody
  • p51 antibody
  • p63 antibody

  • TP63 antibody
  • Tumor protein p53 like antibody
  • Tumor protein p63 antibody
  • Tumor protein p73 like antibody

  see all

Protocols

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols