Overview

  • Product name
    Anti-p51B antibody
  • Description
    Rabbit polyclonal to p51B
  • Host species
    Rabbit
  • Specificity
    This antibody is specific for p51B. It does not cross react with p51A
  • Tested applications
    Suitable for: ICC, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    CNFDMDARRNKQQRIKEEGE

    , corresponding to C terminal amino acids 662-680 of Human p51B.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human Cell Line K562.

Properties

Applications

Our Abpromise guarantee covers the use of ab2505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC 1/300.
WB 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).

Target

  • Relevance
    p51 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
  • Cellular localization
    Nuclear
  • Database links
    • Alternative names
      • AIS antibody
      • p51 antibody
      • p63 antibody
      • TP63 antibody
      • Tumor protein p53 like antibody
      • Tumor protein p63 antibody
      • Tumor protein p73 like antibody
      see all

    Images

    • Western blot - Anti-p51B antibody (ab2505)
      Western blot - Anti-p51B antibody (ab2505)
      ab2505 detects an approximately 75kDa protein in mouse lung. As expected, most of the p51B protein in the human K562 tumour cell line is degraded. ab2505 detects an approximately 75kDa protein in mouse lung. As expected, most of the p51B protein in the human K562 tumour cell line is degraded.

    References

    ab2505 has not yet been referenced specifically in any publications.

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