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Products:Cell Biology >> Apoptosis >> Nucleus >> Other
Overview
Product name
Anti-p51B antibody
Description
Rabbit polyclonal to p51B
Specificity
This antibody is specific for p51B. It does not cross react with p51A
Tested applications
ICC, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide: CNFDMDARRNKQQRIKEEGE, corresponding to C terminal amino acids 662-680 of Human p51B.
CNFDMDARRN KQQRIKEEGE
Positive control
Human Cell Line K562.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Cell Biology >> Apoptosis >> Nucleus >> Other
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Western blot - p51B antibody (ab2505)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2505 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC
ICC: 1/300ICC: 1/300
WB: 1/1000Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).
Target
Relevance
p51 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Cellular localization
Nuclear
Alternative names
- AIS antibody
- p51 antibody
- p63 antibody
see all
Database links
- Entrez Gene: 8626 Human
- SwissProt: Q9H3D4 Human
Anti-p51B antibody images:
Western blot - p51B antibody (ab2505)
Predicted band size : 51 kDa
ab2505 detects an approximately 75kDa protein in mouse lung. As expected, most of the p51B protein in the human K562 tumour cell line is degraded.
References for Anti-p51B antibody (ab2505)
ab2505 has not yet been referenced specifically in any publications.
Publishing research using ab2505? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"