Anti-p53 AIP1 antibody (ab3678)

Product name

Anti-p53 AIP1 antibody
See all p53 AIP1 products (3) ...

Description

Rabbit polyclonal to p53 AIP1

Tested applications

WB, IP, ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide: GSAFELSYDQKKAPLR, corresponding to C terminal amino acids 107-122 of Human p53 AIP1.

GSAFELSYDQKKAPLR

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Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.02% sodium azide

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Primary antibody notes

The novel protein p53 AIP1, p53-regulated apoptosis inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53 AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46,p53 AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53 AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53 AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser 46 regulates the transcriptional activation of this apoptosis inducing gene.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> p53 pathway
Cell Biology >> Apoptosis >> Intracellular >> p53 Pathway