Overview

  • Product nameAnti-p53 BP3 antibody
    See all p53 BP3 primary antibodies
  • Description
    Mouse monoclonal to p53 BP3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 98-206 of Human p53 BP3

Properties

Applications

Our Abpromise guarantee covers the use of ab56640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
    • Tissue specificityExpressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.
    • Involvement in diseaseDefects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP31 inheritance is autosomal dominant.
    • Sequence similaritiesContains 1 RING-type zinc finger.
    • Post-translational
      modifications
      Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.
      Sumoylated.
    • Cellular localizationNucleus. Nucleus > PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
    • Information by UniProt
    • Database links
    • Alternative names
      • AW105885 antibody
      • E3 ubiquitin protein ligase Topors antibody
      • E3 ubiquitin-protein ligase Topors antibody
      • LUN antibody
      • p53 binding protein 3 antibody
      • p53 BP3/LUN antibody
      • p53-binding protein 3 antibody
      • p53BP3 antibody
      • p53BP3/LUN antibody
      • Retinitis pigmentosa 31 antibody
      • RP31 antibody
      • SUMO1 protein E3 ligase Topors antibody
      • SUMO1-protein E3 ligase Topors antibody
      • Topoisomerase I binding arginine/serine rich antibody
      • Topoisomerase I binding arginine/serine rich protein antibody
      • Topoisomerase I binding protein antibody
      • Topoisomerase I binding RING finger protein antibody
      • Topoisomerase I-binding arginine/serine-rich protein antibody
      • Topoisomerase I-binding RING finger protein antibody
      • Topoisomerase I-binding RS protein antibody
      • Topors antibody
      • TOPRS_HUMAN antibody
      • TP53BPL antibody
      • Tumor protein p53 binding protein antibody
      • Tumor suppressor p53 binding protein 3 antibody
      • Tumor suppressor p53-binding protein 3 antibody
      see all

    Anti-p53 BP3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56640 p53 BP3 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-p53 BP3 antibody (ab56640)

    ab56640 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"