• Product name
  • Description
    Rabbit polyclonal to p57 Kip2
  • Tested applications
    Suitable for: IHC-Pmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Human p57 Kip2 (C terminal).

  • Positive control
    • Colon carcinoma or placenta.



Our Abpromise guarantee covers the use of ab80703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at a concentration of 10 - 20 µg/ml for 30 min at RT. Perform heat mediated antigen retrieval by boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min, followed by cooling at RT for 20 min, before commencing with IHC staining protocol.

  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
    • Tissue specificity
      Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
    • Involvement in disease
      Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
      Note=Defects in CDKN1C are involved in tumor formation.
    • Sequence similarities
      Belongs to the CDI family.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • Beckwith Wiedemann syndrome antibody
      • BWCR antibody
      • BWS antibody
      • CDKI antibody
      • CDKN 1C antibody
      • CDKN1C antibody
      • CDN1C_HUMAN antibody
      • Cyclin dependent kinase inhibitor 1C antibody
      • Cyclin dependent kinase inhibitor p57 antibody
      • Cyclin-dependent kinase inhibitor 1C antibody
      • Cyclin-dependent kinase inhibitor p57 antibody
      • KIP 2 antibody
      • KIP2 antibody
      • p57 antibody
      • p57 Kip 2 antibody
      • p57KIP2 antibody
      • WBS antibody
      see all

    Anti-p57 Kip2 antibody images

    • Formalin-fixed, paraffin-embedded human colon cancer stained with ab80703 at 20µg/ml using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.

    References for Anti-p57 Kip2 antibody (ab80703)

    ab80703 has not yet been referenced specifically in any publications.

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