Anti-p57 Kip2 (phospho T310) antibody (ab61064)

Overview

  • Product name
    Anti-p57 Kip2 (phospho T310) antibody
    See all p57 Kip2 primary antibodies
  • Description
    Rabbit polyclonal to p57 Kip2 (phospho T310)
  • Specificity
    Ab61064 detects endogenous levels of p57 Kip2 only when phosphorylated at threonine 310.
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized phosphopeptide derived from human p57 Kip2 around the phosphorylation site of threonine 310(E-Q-TP-P-R).

  • Positive control
    • Human placenta tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab61064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 32 kDa.
ELISA 1/5000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • Tissue specificity
    Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
  • Involvement in disease
    Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=Defects in CDKN1C are involved in tumor formation.
  • Sequence similarities
    Belongs to the CDI family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beckwith Wiedemann syndrome antibody
    • BWCR antibody
    • BWS antibody
    • CDKI antibody
    • CDKN 1C antibody
    • CDKN1C antibody
    • CDN1C_HUMAN antibody
    • Cyclin dependent kinase inhibitor 1C antibody
    • Cyclin dependent kinase inhibitor p57 antibody
    • Cyclin-dependent kinase inhibitor 1C antibody
    • Cyclin-dependent kinase inhibitor p57 antibody
    • KIP 2 antibody
    • KIP2 antibody
    • p57 antibody
    • p57 Kip 2 antibody
    • p57KIP2 antibody
    • WBS antibody
    see all

Images

  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using ab61064 at 1/50-1/100 dilution with or without addition of Phospho-peptide.


  • Predicted band size : 32 kDa

    Western Blot analysis of K562 cell lysates labeling p57 Kip2 (phospho T310) with ab61064 at 0.01U/ml for 15 minutes. The lane on the right is blocked with the phospho peptide.

References

ab61064 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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