Overview

  • Product nameAnti-P5CS antibody
    See all P5CS primary antibodies
  • Description
    Goat polyclonal to P5CS
  • Specificityab106807 is expected to recognize both reported isoforms (NP_002851.2; NP_001017423.1).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Horse, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    C-SEHGSLKYLH

    , corresponding to C terminal amino acids 775-784 of Human P5CS (NP_002851.2).

  • Positive control
    • MCF7 cell lysate
  • General notes


Properties

Applications

Our Abpromise guarantee covers the use of ab106807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 87 kDa).

Target

  • PathwayAmino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
    Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
  • Involvement in diseaseDefects in ALDH18A1 are the cause of mental retardation-joint hypermobility-skin laxity with or without metabolic abnormalities (MRJHSL) [MIM:612652]. Clinical manifestations include microcephaly, progressive neurologic dysfunction, mental retardation, progeroid appearance, joint hypermobility, skin laxity and hyperelasticity, cataracts. Some patients manifest metabolic disturbances such as hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia.
  • Sequence similaritiesIn the N-terminal section; belongs to the glutamate 5-kinase family.
    In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • FormP5CS catalyzes the ATP- and NADPH-dependent conversion of L-glutamate to glutamic gamma-semialdehyde, which is the metabolic precursor for proline biosynthesis. There are 2 isoforms produced by alternative splicing.
  • Alternative names
    • 2810433K04Rik antibody
    • AI429789 antibody
    • Aldehyde dehydrogenase 18 family member A1 antibody
    • Aldehyde dehydrogenase 18A1 antibody
    • Aldehyde dehydrogenase family 18 member A1 antibody
    • ALDH18A1 antibody
    • Delta 1 pyrroline 5 carboxylate synthetase antibody
    • Delta1 pyrroline 5 carboxlate synthetase antibody
    • Gamma-glutamyl kinase antibody
    • Gamma-glutamyl phosphate reductase antibody
    • GK antibody
    • Glutamate-5-semialdehyde dehydrogenase antibody
    • Glutamyl-gamma-semialdehyde dehydrogenase antibody
    • GPR antibody
    • GSAS antibody
    • MGC117316 antibody
    • MGC32233 antibody
    • P5CS antibody
    • P5CS_HUMAN antibody
    • PYCS antibody
    • Pyrroline 5 carboxylate synthetase (glutamate gamma semialdehyde synthetase) antibody
    see all

Anti-P5CS antibody images

  • Anti-P5CS antibody (ab106807) at 0.300000011921 µg/ml + Mouse NIH3T3 cell Lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa
  • Anti-P5CS antibody (ab106807) at 1 µg/ml + MCF7 cell lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa
    Primary incubation was 1 hour.

References for Anti-P5CS antibody (ab106807)

ab106807 has not yet been referenced specifically in any publications.

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