• Product nameAnti-p73 (phospho Y99) antibody
    See all p73 primary antibodies
  • Description
    Rabbit polyclonal to p73 (phospho Y99)
  • Specificityab38457 recognises endogenous levels of p73 only when phosphorylated at tyrosine 99.
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human p73 around the phosphorylation site of tyrosine 99 (SPYpAQ).

  • Positive control
    • Human lung carcinoma tissue, extracts from K562 cells.



Our Abpromise guarantee covers the use of ab38457 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 70 kDa.
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.


  • FunctionParticipates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
  • Tissue specificityExpressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
  • Sequence similaritiesBelongs to the p53 family.
    Contains 1 SAM (sterile alpha motif) domain.
  • DomainPossesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain.
    The WW-binding motif mediates interaction with WWOX.
  • Post-translational
    Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity.
    Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
    Ubiquitinated; leading to its degradation by the proteasome.
  • Cellular localizationNucleus. Accumulates in the nucleus in response to DNA damage.
  • Information by UniProt
  • Database links
  • Alternative names
    • p53 like transcription factor antibody
    • p53 related protein antibody
    • p53-like transcription factor antibody
    • p53-related protein antibody
    • p73 antibody
    • P73_HUMAN antibody
    • TP73 antibody
    • Tumor protein p73 antibody
    see all

Anti-p73 (phospho Y99) antibody images

  • All lanes : Anti-p73 (phospho Y99) antibody (ab38457) at 1/500 dilution

    Lane 1 : untreated extracts from K562 cells
    Lane 2 : Pervanadate treated extracts from K562 cells

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 70 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemical analysis of p73 (phospho Y99) in paraffin embedded human lung carcinoma tissue sections using 1/50 ab38457. Left: untreated sample. Right: sample pretreated with phosphopeptide (negative control).

References for Anti-p73 (phospho Y99) antibody (ab38457)

ab38457 has not yet been referenced specifically in any publications.

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