Anti-p75 NGF Receptor antibody [5C4B9] (ab86768)


  • Product nameAnti-p75 NGF Receptor antibody [5C4B9]
    See all p75 NGF Receptor primary antibodies
  • Description
    Mouse monoclonal [5C4B9] to p75 NGF Receptor
  • SpecificityPlease note that, despite having used an immunogen that is 100% homologous with the human and rat p75 NGF receptor proteins, Abcam could not get this antibody to detect p75 NGF receptor in human or rat tissue lysates. Abcam would welcome feedback from customers that have used ab86768 in either of these species!
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide derived from within residues 250 - 350 of Human p75 NGF Receptor.

  • Positive control
    • This antibody gave a positive signal in the following mouse tissue lysates: Brain; Spinal Cord; Heart.
  • General notes

    This antibody is available as an azide-free product (see ab175435).



Our Abpromise guarantee covers the use of ab86768 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 5 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 75 kDa).


  • FunctionLow affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
  • Sequence similaritiesContains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • DomainDeath domain is responsible for interaction with RANBP9.
    The extracellular domain is responsible for interaction with NTRK1.
  • Post-translational
    N- and O-glycosylated.
    O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
    Phosphorylated on serine residues.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD271 antibody
    • CD271 antigen antibody
    • Gp80 LNGFR antibody
    • Gp80-LNGFR antibody
    • Low affinity nerve growth factor receptor antibody
    • Low affinity neurotrophin receptor p75NTR antibody
    • Low-affinity nerve growth factor receptor antibody
    • Nerve growth factor receptor antibody
    • Nerve growth factor receptor TNFR superfamily member 16 antibody
    • NGF receptor antibody
    • Ngfr antibody
    • p75 ICD antibody
    • p75 Neurotrophin receptor antibody
    • p75 NTR antibody
    • p75(NTR) antibody
    • p75NTR antibody
    • TNFR Superfamily Member 16 antibody
    • TNFRSF16 antibody
    • TNR16_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 16 antibody
    see all

Anti-p75 NGF Receptor antibody [5C4B9] images

  • All lanes : Anti-p75 NGF Receptor antibody [5C4B9] (ab86768) at 5 µg/ml

    Lane 1 : Brain (Mouse) Tissue Lysate
    Lane 2 : Spinal Cord (Mouse) Tissue Lysate
    Lane 3 : Heart (Mouse) Tissue Lysate

    Lysates/proteins at 20 µg per lane.

    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 75 kDa
    Observed band size : 74 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 16 minutes

References for Anti-p75 NGF Receptor antibody [5C4B9] (ab86768)

ab86768 has not yet been referenced specifically in any publications.

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