Overview

  • Product nameAnti-p75 NGF Receptor antibody [MLR2]
    See all p75 NGF Receptor primary antibodies
  • Description
    Mouse monoclonal [MLR2] to p75 NGF Receptor
  • Tested applicationsSuitable for: Flow Cyt, ELISA, Competitive ELISA, ICC/IFmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Human p75 coupled to an Fc fragment

  • Positive control
    • Motor neurons in spinal cord with lesioned sciatic nerve

Properties

Applications

Our Abpromise guarantee covers the use of ab61425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 20 µg/ml. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ELISA 1/5000.
Competitive ELISA Use at an assay dependent concentration. PubMed: 22292018
ICC/IF Use at an assay dependent concentration.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionLow affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    • Sequence similaritiesContains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • DomainDeath domain is responsible for interaction with RANBP9.
      The extracellular domain is responsible for interaction with NTRK1.
    • Post-translational
      modifications
      N- and O-glycosylated.
      O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
      Phosphorylated on serine residues.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD271 antibody
      • CD271 antigen antibody
      • Gp80 LNGFR antibody
      • Gp80-LNGFR antibody
      • Low affinity nerve growth factor receptor antibody
      • Low affinity neurotrophin receptor p75NTR antibody
      • Low-affinity nerve growth factor receptor antibody
      • Nerve growth factor receptor antibody
      • Nerve growth factor receptor TNFR superfamily member 16 antibody
      • NGF receptor antibody
      • Ngfr antibody
      • p75 ICD antibody
      • p75 Neurotrophin receptor antibody
      • p75 NTR antibody
      • p75(NTR) antibody
      • p75NTR antibody
      • TNFR Superfamily Member 16 antibody
      • TNFRSF16 antibody
      • TNR16_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 16 antibody
      see all

    Anti-p75 NGF Receptor antibody [MLR2] images

    • Ab61425 uptake into mesenteric nerves following in vivo administration into adult rat.

    References for Anti-p75 NGF Receptor antibody [MLR2] (ab61425)

    This product has been referenced in:
    • Zhang C  et al. Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells. PLoS One 7:e30684 (2012). Competitive ELISA . Read more (PubMed: 22292018) »
    • Huh CY  et al. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. J Neurosci 28:1404-9 (2008). Read more (PubMed: 18256260) »

    See all 5 Publications for this product

    Product Wall

    Thanks for your phone call last week and for your patience while I have been in touch with the lab about ab61425. I apologize for the delay in getting back to you. I was told that this antibody was generated against the extracellular domain of ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"