Overview

  • Product name
  • Description
    Rabbit polyclonal to PABPC4
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 525-575 of Human PABPC4 (NP_003810.1).

  • Positive control
    • Human Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma and Prostate Carcinoma. Mouse Teratoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab101492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Antigen retrieval is recommended. Antigen retrieval with citrate buffer will enhance staining.

Target

  • Function
    Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.
  • Tissue specificity
    Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
  • Sequence similarities
    Belongs to the polyadenylate-binding protein type-1 family.
    Contains 1 PABC domain.
    Contains 4 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
  • Cellular localization
    Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activated platelet protein 1 antibody
    • Activated-platelet protein 1 antibody
    • APP 1 antibody
    • APP-1 antibody
    • APP1 antibody
    • FLJ43938 antibody
    • Inducible poly(A) binding protein antibody
    • Inducible poly(A)-binding protein antibody
    • iPABP antibody
    • IPABP4 antibody
    • PABP 4 antibody
    • PABP-4 antibody
    • PABP4 antibody
    • PABP4_HUMAN antibody
    • PABPC 4 antibody
    • PABPC4 antibody
    • Poly A binding protein cytoplasmic 4 antibody
    • Poly(A) binding protein 4 antibody
    • Poly(A) binding protein cytoplasmic 4 (inducible form) antibody
    • Poly(A) binding protein cytoplasmic 4 antibody
    • Poly(A)-binding protein 4 antibody
    • Polyadenylate binding protein 4 antibody
    • Polyadenylate-binding protein 4 antibody
    • Polyadenylate-binding protein, cytoplasmic, 4 antibody
    • Polyadenylate-binding protein, inducible antibody
    see all

Images

  • ab101492 at 1/250 dilution staining PABPC4 in a Formalin-fixed, paraffin-embedded section of Human ovarian carcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
  • ab101492 at 1/250 dilution staining PABPC4 in a formalin-fixed, paraffin-embedded section of mouse teratoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.

References

ab101492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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