• Product nameAnti-PACE4 antibody
    See all PACE4 primary antibodies
  • Description
    Mouse monoclonal to PACE4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 860-970 of Human PACE4



Our Abpromise guarantee covers the use of ab58226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionLikely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.
    • Tissue specificityEach PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.
    • Sequence similaritiesBelongs to the peptidase S8 family.
      Contains 1 homo B/P domain.
      Contains 1 PLAC domain.
    • DomainThe propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain.
    • Cellular localizationSecreted; Endomembrane system. Retained intracellularly probably through a hydrophobic cluster in their C-terminus and Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
    • Information by UniProt
    • Database links
    • Alternative names
      • Paired basic amino acid cleaving enzyme 4 antibody
      • Paired basic amino acid cleaving system 4 antibody
      • PCSK6 antibody
      • PCSK6_HUMAN antibody
      • Proprotein convertase subtilisin/kexin type 6 antibody
      • SPC4 antibody
      • Subtilisin like protease antibody
      • Subtilisin-like proprotein convertase 4 antibody
      • subtilisin/kexin like protease PACE4 antibody
      • Subtilisin/kexin-like protease PACE4 antibody
      see all

    Anti-PACE4 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58226 PACE4 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-PACE4 antibody (ab58226)

    ab58226 has not yet been referenced specifically in any publications.

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    We unfortunately haven't tested this antibody with endogenous lysates so I am sorry we do not have data for comparison. However as this antibody has passed the qc test so it should be able to detect the protein. I app...

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