Overview

  • Product nameAnti-PACRG antibody
    See all PACRG primary antibodies
  • Description
    Rabbit polyclonal to PACRG
  • Tested applicationsSuitable for: WB, ELISA, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Zebrafish
  • Immunogen

    Synthetic peptide:

    NGSYSLPRLECS

    , corresponding to internal sequence amino acids 204-215 of Human PACRG, conjugated to KLH.

  • Positive control
    • Human colon tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab115465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
ELISA 1/2000 - 1/10000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

Target

  • FunctionSuppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
  • Tissue specificityExpressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ32724 antibody
    • GLUP antibody
    • HAK005771 antibody
    • Molecular chaperone/chaperonin binding protein antibody
    • Molecular chaperone/chaperonin-binding protein antibody
    • PACRG antibody
    • PACRG_HUMAN antibody
    • PARK 2 co regulated antibody
    • PARK 2 coregulated antibody
    • PARK2 co regulated antibody
    • PARK2 coregulated antibody
    • PARK2 coregulated gene protein antibody
    • PARK2CRG antibody
    • Parkin co regulated gene antibody
    • Parkin co regulated gene protein antibody
    • Parkin coregulated gene antibody
    • Parkin coregulated gene protein antibody
    • RP3 495O10.2 antibody
    see all

Anti-PACRG antibody images

  • ab115465, at 2.5 µg/ml, staining PACRG in formalin fixed, paraffin embedded Human colon tissue by Immunohistochemistry.

References for Anti-PACRG antibody (ab115465)

ab115465 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"