Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab4090 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).

Target

  • FunctionSuppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
  • Tissue specificityExpressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ32724 antibody
    • GLUP antibody
    • HAK005771 antibody
    • Molecular chaperone/chaperonin binding protein antibody
    • Molecular chaperone/chaperonin-binding protein antibody
    • PACRG antibody
    • PACRG_HUMAN antibody
    • PARK 2 co regulated antibody
    • PARK 2 coregulated antibody
    • PARK2 co regulated antibody
    • PARK2 coregulated antibody
    • PARK2 coregulated gene protein antibody
    • PARK2CRG antibody
    • Parkin co regulated gene antibody
    • Parkin co regulated gene protein antibody
    • Parkin coregulated gene antibody
    • Parkin coregulated gene protein antibody
    • RP3 495O10.2 antibody
    see all

Anti-PACRG antibody images

  • All lanes : Anti-PACRG antibody (ab4090) at 1/1500 dilution

    Lane 1 : Mouse embryonic fibroblast (MEF) whole cell lysate
    Lane 2 : Mouse embryonic fibroblast (MEF) whole cell lysate with immunising peptide

    Lysates/proteins at 35 µg per lane.

    Secondary
    IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

    Predicted band size : 33 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

References for Anti-PACRG antibody (ab4090)

This product has been referenced in:
  • Gavino C & Richard S Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus. Mol Cell Neurosci 47:100-7 (2011). Read more (PubMed: 21447392) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"