Overview

  • Product name
  • Description
    Rabbit polyclonal to PACS1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to C terminal residues of human PACS1 (Phosphofurin acidic cluster sorting protein 1)

Properties

Applications

Our Abpromise guarantee covers the use of ab56072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 105 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
    • Involvement in disease
      Mental retardation, autosomal dominant 17
    • Sequence similarities
      Belongs to the PACS family.
    • Cellular localization
      Golgi apparatus, trans-Golgi network. Localizes in the perinuclear region, probably the TGN.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cytosolic sorting protein PACS1 antibody
      • PACS 1 antibody
      • PACS-1 antibody
      • Pacs1 antibody
      • PACS1_HUMAN antibody
      • Phosphofurin acidic cluster sorting protein 1 antibody
      see all

    Images



    • Predicted band size : 105 kDa

      Image from Yi L et al, J Biol Chem. 2010 Oct 1;285(40):30884-905. Epub 2010 Jul 9, Fig 4. DOI 10.1074/jbc.M110.135947

    References

    This product has been referenced in:
    • Budhiraja S  et al. Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function. J Virol 89:3557-67 (2015). Read more (PubMed: 25589658) »
    • Werneburg NW  et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J Biol Chem : (2012). WB ; Human . Read more (PubMed: 22645134) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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