Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab121136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • Tissue specificity
    Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
  • Sequence similarities
    Belongs to the PACS family.
  • Cellular localization
    Endoplasmic reticulum lumen. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6720425G15Rik antibody
    • AW208651 antibody
    • AW489976 antibody
    • E230011J22 antibody
    • FLJ25488 antibody
    • KIAA0602 antibody
    • mKIAA0602 antibody
    • PACS 2 antibody
    • PACS-2 antibody
    • PACS1 like protein antibody
    • PACS1-like protein antibody
    • PACS1L antibody
    • PACS2 antibody
    • PACS2_HUMAN antibody
    • Phosphofurin acidic cluster sorting protein 1 like antibody
    • Phosphofurin acidic cluster sorting protein 2 antibody
    see all

Images

  • Immunohistochemical staining of paraffin embedded human liver tissue with anti-PACS2 antibody (ab121136; dilution 1:50) showing strong cytoplasmic positivity in hepatocytes.

References

ab121136 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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