• Product nameAnti-PADI4 / PAD4 antibody
    See all PADI4 / PAD4 primary antibodies
  • Description
    Mouse monoclonal to PADI4 / PAD4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 2-111 of Human PADI4/ PAD4



Our Abpromise guarantee covers the use of ab57167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCatalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
    • Tissue specificityExpressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes.
    • Involvement in diseaseGenetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
    • Sequence similaritiesBelongs to the protein arginine deiminase family.
    • Cellular localizationCytoplasm. Nucleus. Cytoplasmic granule. Cytoplasmic granules of eosinophils and neutrophils.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC antibody
      • HL 60 PAD antibody
      • HL-60 PAD antibody
      • PAD 4 antibody
      • PAD antibody
      • PADI 4 antibody
      • PADI 5 antibody
      • PADI H protein antibody
      • Padi4 antibody
      • PADI4_HUMAN antibody
      • PADI5 antibody
      • PDI 4 antibody
      • PDI 5 antibody
      • PDI4 antibody
      • PDI5 antibody
      • Peptidyl arginine deiminase type IV antibody
      • Peptidyl arginine deiminase type V antibody
      • Peptidylarginine deiminase IV antibody
      • Protein arginine deiminase antibody
      • Protein arginine deiminase type 4 antibody
      • Protein arginine deiminase type IV antibody
      • Protein-arginine deiminase type IV antibody
      • Protein-arginine deiminase type-4 antibody
      see all

    Anti-PADI4 / PAD4 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57167 PADI4 / PAD4 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-PADI4 / PAD4 antibody (ab57167)

    This product has been referenced in:

    See 1 Publication for this product

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