Overview

  • Product nameAnti-PAF49 antibody
    See all PAF49 primary antibodies
  • Description
    Rabbit polyclonal to PAF49
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 404-454 of Human PAF49.

Properties

Applications

Our Abpromise guarantee covers the use of ab92428 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
ICC/IF
  • Application notesICC/IF: Use at an assay dependent dilution.
    IHC-P: 1/100 - 1/1500.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.
      Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.
    • Sequence similaritiesBelongs to the eukaryotic RPA34 RNA polymerase subunit family.
    • Post-translational
      modifications
      Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other group.
      Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus > nucleolus. Chromosome. Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.
    • Information by UniProt
    • Database links
    • Alternative names
      • A34.5 antibody
      • Anti sense to ERCC 1 protein antibody
      • Antisense to ERCC-1 protein antibody
      • ASE 1 antibody
      • ASE-1 antibody
      • ASE1 antibody
      • CAST antibody
      • CD3 epsilon associated protein antibody
      • CD3-epsilon-associated protein antibody
      • CD3E antigen, epsilon polypeptide associated protein antibody
      • CD3E associated protein antibody
      • CD3e molecule, epsilon associated protein antibody
      • CD3E-associated protein antibody
      • CD3EAP antibody
      • DNA directed RNA polymerase I subunit RPA34 antibody
      • DNA-directed RNA polymerase I subunit RPA34 antibody
      • MGC118851 antibody
      • PAF 49 antibody
      • RNA polymerase I associated factor PAF49 antibody
      • RNA polymerase I-associated factor PAF49 antibody
      • RPA34_HUMAN antibody
      see all

    Anti-PAF49 antibody images

    • Formaldehyde fixed asynchronous HeLa cells detected with ab92428 at 1/250 dilution

    References for Anti-PAF49 antibody (ab92428)

    ab92428 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"